As a competitive
Loden Request full-text Abstract Context: Following
Can mimic digoxin, Beta-blocker, or CCB toxicity with hypotension and bradycardia
Naloxone may be of value in reversing clonidine toxicity when clonidine is given to treat an acute rise in arterial pressure
Major toxic effects of clonidine include respiratory depression, hypotension, bradycardia, decreased cardiac output, and death
Clonidine is an antihypertensive drug that lowers blood pressure and heart rate by
With massive overdose, clonidine's partial alpha-agonist properties may predominate, resulting in marked hypertension requiring cautious therapy
Methods: This was a retrospective review of a prospective cohort of poisoned patients who took clonidine overdoses (>200 μg)
Administration of naloxone to somnolent pediatric patients with clonidine toxicity awoke the majority (40/51) and resolved bradycardia and hypotension in some
— We would like to report the use of naloxone (Narcan) in the reversal of coma and apnea in a child who had ingested an unknown quantity of clonidine (Catapres)
High blood pressure adds to the workload of the heart and arteries
, clonidine) may cause bradycardia and somnolence, but without bradypnea
Central alpha-2 agonists include clonidine, guanfacine, tizanidine, guanabenz, and methyldopa
toxicity when clonidine is given to treat an acute rise in arterial pressure
However, this conclusion has been based on administration of small doses (2 mg or less) of naloxone
[1][2][3] Opioid overdose reversal medications (OORM), also called naloxone or Narcan ™, can very quickly restore normal breathing for a person whose breathing has slowed down or stopped because of an overdose of prescription opioids or illicit opioids, which includes illicitly manufactured fentanyl and heroin
general feeling of discomfort or illness
While generally safe, at toxic doses clonidine can cause serious cardiopulmonary instability and central nervous system (CNS) depression in
However, this conclusion has been based on administration of small doses (2 mg or less) of naloxone
Current overdose reversal medications— including naloxone (Narcan ®, Kloxxado ®, Zimhi ®, ReVive ®) and nalmefene (Opvee ® )—are approved to reverse overdoses caused by opioids like